期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2009, 期 6, 页码 870-888出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200801024
关键词
Carbohydrates; Asymmetric synthesis; Glycosylation; Oligosaccharides; NMR spectroscopy
资金
- Finnish Funding Agency for Technology and Innovation, TEKES [40134/06]
- Academy of Finland [121335, 122126]
- Magnus Ehrnrooth Foundation
- National Glycoscience Graduate School
- Academy of Finland (AKA) [122126, 121335, 121335, 122126] Funding Source: Academy of Finland (AKA)
b-(1 -> 2)-Linked oligomannosides constitute an important class of carbohydrate structures located on the cell surface of several Candida species, including C. albicans. As a result of the immunostimulating properties of such compounds, the upscaling of their synthesis is relevant. In this paper, a highly stereoselective synthesis of beta-(1 -> 2)-linked oligomannosides was performed by further development of and modifications to the methodologies described earlier in the literature. In addition to the synthesis of fully deprotected beta-(1 -> 2)-linked mannobiose and mannotriose, some preliminary modifications to the oligosaccharide core, resulting in close analogues with biological potential, are presented. The fully deprotected products form potential targets for screening against C. albicans and may also result in new model structures for vaccine development. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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