Continuous-Flow Microreactor Chemistry under High-Temperature/Pressure Conditions

High-temperature organic synthesis can be performed under continuous-flow conditions in a stainless steel microtubular flow reactor capable of achieving temperatures of 350 degrees C and 200 bar. Under these extreme experimental environments transformations normally performed in a high-boiling solvent at reflux temperature - or under sedled-vessel microwave conditions - can be readily converted to a flow regime by using lower boiling solvents in or near their supercritical state. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)