期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2009, 期 36, 页码 6367-6378出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200900999
关键词
Total synthesis; Antitumor agents; Myxobacteria; Natural products; Tubulysins; Pretubulysin
资金
- Deutsche Forschungsgemeinschaft (DFG)
- Fonds der Chemischen Industrie
Pretubulysin, a biosynthetic precursor of the tubulysins, shows potent biological activity in the subnanomolar range towards various tumor cell lines. Its activity is only slightly less than those of the structurally more complex tubulysins. With a straightforward synthesis to hand, pretubulysin is an ideal lead structure for the development of tubulysin-based anticancer drugs ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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