期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2009, 期 11, 页码 1698-1706出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200801221
关键词
Cyclization; Gold; Homogenous catalysis; Hydroalkoxylation; Oxygen heterocycles
资金
- Academic Development Program
- Ministerio de Educacion y Ciencia and FICYT (Spain)
- Deutsche Forschungsgemeinschaft for a postdoctoral fellowship
- Universidade de Santiago de Compostela (Spain)
- Cambridge University Chemistry Laboratory
The AuCl3-catalyzed double hydroalkoxylation of conjugated 7-hydroxyheptynoates offers a convenient route for the synthesis of six-membered cyclic acetals, which are common substructures of polyketide natural products. When conjugated 6-hydroxyhexynoates are used as starting materials, either five-membered cyclic E-enol ethers or the corresponding acetals can be obtained by simply choosing the appropriate reaction solvent. NMR spectroscopic studies were carried out to determine the kinetics and pathway of the latter domino 5-exo cyclization-hydroalkoxylation reaction. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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