期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2009, 期 9, 页码 1435-1444出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200801119
关键词
Heterocycles; Halogenated heterocycles; Antimicrobial activity; Tetrahydropyridines
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico Universal (CNPq) [476634/06-7]
- CAPES
A simple and highly chemoselective method for the synthesis of a large series of novel 6-alkoxy-1-alkyl(aryl)-3-trifluoroacetyl-1,4,5,6-tetrahydropyridines and 1-alkyl(aryl)-6-amino3-trifluoroacetyl-1,4,5,6-tetrahydropyridines, from the reaction of 6-alkoxy-3-trifluoroacetyl-4,5-dihydro-6H-pyrans with primary alkyl and arylamines, in good yields, is reported. Preliminary in vitro antimicrobial activity of the I-alkyl(aryl)-6-amino-3-trifluoroacetyl-1,4,5,6-tetrahydropyridine series was assessed against a variety of microorganisms including yeast-like fungi, bacteria and algae, and some of these compounds exhibit significant antimicrobial activity. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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