4.5 Article

Reaction of the Electrogenerated Cyanomethyl Anion with Carbonyl Compounds: A Clean and Safe Synthesis of β-Hydroxynitriles

期刊

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2009, 期 23, 页码 3863-3866

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200900527

关键词

Green chemistry; Electrochemistry; Nucleophilic addition; Carbanions; Cyanides

资金

  1. Ministero dell'Universitita e della Ricerca (MIUR)
  2. CNR (Rome)

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The electrogenerated cyanomethyl anion reacts with carbonyl compounds to yield the corresponding beta-hydroxynitriles in moderate to high yields. The reported methodology is very clean and safe, avoiding the use of any classical base or catalyst. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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