期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2009, 期 15, 页码 2441-2453出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200801170
关键词
Carbohydrates; Glycoconjugates; Multivalency; Cycloaddition; Click chemistry; Ligand design
资金
- Direccion General de Itivestigacion Cientifica y Tecnica (DGICYT) [CTQ2005-02219]
Mannose (alpha-Man)-containing neoglycoconjugates possessing aliphatic-, aromatic-, and carbohydrate-centered architectures and differing in structural characteristics such as valency, topology, and nature of the linker have been synthesized using click chemistry that shows its value as an efficient and versatile methodology for, accessing tailor-made multivalent neoglycoconjugates. The binding behaviour of these glycomimics toward Concanavalin A (Con A) has been evaluated to determine the influence of the structural parameters. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451. Weinheim, Germany, 2009)
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