期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2009, 期 20, 页码 3368-3386出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200900122
关键词
Alkaloids; Biological activity; Copper catalysis; Cyclopeptide alkaloids; Macrocycles; Total synthesis
资金
- Centre National de la Recherche Scientifique (CNRS)
- Ministere de la Recherche
A full account of the total syntheses of the cyclopeptide alkaloids paliurine E and F, ziziphine N and Q, abyssenine A, and mucronine E is provided. A key feature of the syntheses involves an intramolecular amidation of a vinyl iodide, which allows us simultaneously to address two synthetic challenges associated with cyclopeptide alkaloids: the formation of the enamide and macrocyclization. We also document the use of other strategies for the macrocyclization step, as well as the evaluation of the antibacterial and cytotoxic properties of the natural products and analogues obtained. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据