期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2009, 期 36, 页码 6281-6288出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200900927
关键词
Iron; Grignard reaction; Sulfur; Homogeneous catalysis; Cross-coupling
资金
- Swiss National Science Foundation (Bern)
- Roche Research Foundation (Basel)
Alk-2-enesulfonyl chlorides 1-4 were synthesized by the BCl3-promoted ene reaction of alkenes with SO2. These sulfonyl chlorides were then used as electrophilic partners in iron-catalyzed desulfinylative cross-coupling reactions with different Grignard reagents (aromatic, aliphatic, and heteroaromatic). The reaction can be catalyzed with even 2 mol-% of the simple iron salt Fe(acac)(3). The regioselectivity of these allylations was studied by using sulfonyl chlorides 3 and 4 with aryl Grignard reagents. The scope of these allylations was further extended by the coupling of ester-substituted alk-2-enesulfonyl chloride 10 with aromatic Grignard reagents. Symmetrical products were synthesized by double C-C allylation with the use of 2-methylidenepropane-1,3-disulfonyl chloride (12). ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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