期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2008, 期 22, 页码 3781-3784出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200800447
关键词
coumarins; fungi; natural products; polyketides; protease inhibitors
The bioactivity-guided fractionation of metabolites from an Epicoccum sp. isolated from the fruiting body of the tree fungus Pholiota squarrosa led to the discovery of a new inhibitor of the serine protease alpha-chymotrypsin. The structure of the active compound, epicoccalone (1), was fully elucidated by spectrometric and spectroscopic methods, revealing a coumarin ring system with an unprecedented substitution pattern. Two isobenzofuran-derived co-metabolites were identified that are remarkably similar to the epicoccalone coumarin core, strongly suggesting that these metabolites share the same orsellinic acid like polyketide pathway. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
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