期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2008, 期 9, 页码 1625-1631出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200701001
关键词
nitrogen heterocycles; ruthenium; oxidative cyclization; Friedlander reaction
In a modification of the Friedlander reaction, 2-aminobenzyl alcohol is oxidatively cyclized with a variety of ketones to yield substituted quinolines. Of all the ruthenium catalysts that were tested for this reaction, the second-generation Grubbs' catalyst gives the highest quinoline yield, in combination with KOtBu as a base. The presence of a hydrogen acceptor is required to regenerate the catalyst. Also the reaction mechanism is discussed, and the results show that there are possibly two different pathways towards quinolines.
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