Copper-catalyzed asymmetric allylic alkylation

Over the past decade, much effort has been put on designing efficient chiral ligands and screening of the different parameters that govern the main challenges of asymmetric S(N)2' reactions, namely chemo-, regio- and enantioselectivity. This review traces the evolution of the methodologies for creating stereogenic centers through asymmetric copper-catalyzed allylic alkylation with the use of different organometallic reagents and their subsequent applications. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).