期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2008, 期 9, 页码 1489-1505出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200700946
关键词
synthesis; nucleoside analogues; nucleoside conformation; conformational analysis
This review describes some approaches in the synthesis of conformationally restricted nucleoside analogues. The focus is on the preparation of nucleosides as monomers modified only on the pentofurano sugar moiety, with an additional linkage capable of modulating the dynamic conformational equilibrium of natural nucleosides. The results of the different structural modifications in terms of pseudorotational analysis, as well as the potential use of such conformationally restricted nucleoside analogues, are briefly presented.
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