期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2008, 期 33, 页码 5518-5525出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200800677
关键词
Polyamine; Hydroxylamine; Solid-phase synthesis; Elimination; Toxin
资金
- Swiss National Science Foundation
Orthogonally protected, N-hydroxylated, linear tri- and tetra- amines were efficiently synthesised on Merrifield resin, which was modified with a phenethyl bromide linker. The polyamine frameworks were convergently prepared from the centre with reductive aminations and nucleophilic substitutions to elongate the polyamine backbone. The required N-hydroxy groups were introduced during the cleavage of the polyamine derivatives from the resin through Cope elimination. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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