期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2008, 期 26, 页码 4391-4399出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200800371
关键词
nitrogen heterocycles; oxygen heterocycles; spiro compounds; synthetic methods
The 1-oxa-7-azaspiro[5.5]undecane, 1-oxa-6-azaspiro[4.5]decane, 1-oxa-7-azaspiro[5.4]decane and 1-oxa-6-azaspiro[4.4]nonane ring systems are found as the cores of natural or synthetic products that possess significant biological activities. Because of their potential applications, together with the novelty of their skeletons, these compounds represent challenging targets for chemical synthesis. In this review we summarize the different strategies developed for the synthesis of these spiroaminals. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008.
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