期刊
EUROPEAN JOURNAL OF ORAL SCIENCES
卷 122, 期 6, 页码 397-403出版社
WILEY-BLACKWELL
DOI: 10.1111/eos.12152
关键词
anti-biofilm activity; antimicrobial activity; Rothia sp; zinc oxide nanoparticles
资金
- National Plan for Sciences and Technology (NPST) Project, King Saud University, Riyadh [12-NAN-2490-2]
- Visiting Professorship Program (VPP), King Saud University
Species of the genus Rothia that inhabit the oral cavity have recently been implicated in a number of diseases. To minimize their role in oral infections, it is imperative to reduce and/or control the growth and biofilm formation activity of Rothia spp. In this study, two bacterial isolates, Ora-7 and Ora-16, were obtained from the oral cavity of a healthy male subject and identified as Rothia dentocariosa and Rothia mucilaginosa, respectively, using a polyphasic taxonomic approach. Antimicrobial and anti-biofilm formation activities of zinc oxide nanoparticles (ZnO-NPs), of average size 35nm, were assessed in in vitro assays using Crystal Violet and live and dead staining techniques. The ZnO-NPs exhibited an IC50 value of 53 and 76gml(-1) against R.dentocariosa and R.mucilaginosa, respectively. Biofilm-formation assays, performed on the surfaces of polystyrene plates, artificial teeth, and dental prostheses, revealed the efficacy of ZnO-NPs as a potential antibacterial agent for controlling the growth of Rothia isolates in both planktonic form and biofilm.
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