期刊
EUROPEAN JOURNAL OF ORAL SCIENCES
卷 117, 期 4, 页码 474-478出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0722.2009.00642.x
关键词
adhesion; Candida albicans; Candida dubliniensis; monoclonal antibodies; salivary secretory IgA
资金
- Department of Education, Universities and Research [IT-264-07]
- Department of Industry, Trade and Tourism, Basque Government [S-P08BUN10]
The aim of this study was to assess the role of whole saliva, four saliva-derived preparations, and six monoclonal antibodies (mAbs), directed against components of the cell wall of Candida albicans, on the adhesion of C. albicans and Candida dubliniensis to human epithelial cells (HEC). C. albicans serotype A NCPF 3153 and C. albicans serotype B ATCC 90028 showed higher adhesion to HEC than C. dubliniensis NCPF 3949. Pooled whole saliva was more efficient than salivary secretory immunoglobulin A, partially purified by chromatography, at inhibiting the adhesion of C. albicans serotype A NCPF 3153 to HEC. Monoclonal antibodies C7, 14-8, and 26G7 were the most potent inhibitors of adhesion. Our results show that mAbs can mimic the inhibition of adhesion of C. albicans to HEC that is mediated by human saliva.
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