期刊
EUROPEAN JOURNAL OF ORAL SCIENCES
卷 117, 期 3, 页码 248-254出版社
WILEY
DOI: 10.1111/j.1600-0722.2009.00620.x
关键词
cytokines; inflammation; matrix metalloproteinase-8; tooth extraction; wound healing
资金
- Academy of Finland
- Northern Finland Cancer Foundation
- Oulu University Central Hospital EVO-grants
- Helsinki University Central Hospital EVO-grants
- Finnish Dental Association Apollonia and Finnish Cultural Foundation
Matrix metalloproteinase-8 (MMP-8) participates in skin wound healing and inflammation. We hypothesized that MMP-8 plays a role in wound healing after tooth extraction and in periapical inflammation. Bone formation, collagen metabolism, and inflammation in tooth extraction socket and in periapical lesions were analyzed in wild-type mice and in MMP-8-deficient (MMP-8(-/-)) mice. New trabecular bone area in the extraction sockets and in periapical lesions were similar in both groups. In extraction sockets significantly more type III procollagen was synthesized, and the neutrophil and MMP-9 levels were lower in MMP-8(-/-) mice. The amount of Fas ligand, identified as a substrate for MMP-8, was lower in alveolar mucosa but higher in alveolar bone of MMP-8(-/-) mice. These results indicate that MMP-8 can modulate inflammation and collagen metabolism of alveolar bone and mucosa.
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