Predictive factors for recurrence of ovarian mature cystic teratomas after surgical excision

Objective: To study the recurrence rate and predictive factors for recurrence after surgical excision of ovarian mature cystic teratomas (MCT). Study design: Retrospective study of 382 patients who underwent surgical excision of MCT and whose post-surgical follow-up data were available over six months. Patients who underwent concomitant oophorectomy or had a history of oophorectomy were excluded. Medical records were reviewed for evidence of recurrence. The Cox-hazard model was used for the estimation of predictive factors for recurrence. Categorical data were compared using the Chi-square and Fisher's exact tests. Results: There were 16 recurrences within a mean follow-up period of 43.0 months, with a recurrence rate of 4.2%. Young age (<30 years old, Y) (hazard ratio (HR) 2.98; 95% confidence interval (Cl) 1.04-8.62, P = 0.043), large cyst (>= 8 cm in diameter, L) (HR 2.75; 95% CI 1.03-7.37, P = 0.044), and bilaterality (B) (HR 2.88; 95% CI 1.07-7.76, P = 0.036) were shown to be significant predictive factors. When a patient had all these three factors, the recurrence rate was 21.0%, otherwise 3.4% (P < 0.01). Patients with Y + L, Y + B, and B + L also showed significantly higher recurrence rate (21,4%, 15.9%, and 11.4%, respectively). Conclusion: The long-term recurrence rate after surgical excision of MCT in this study is 4.2%. A patient with young age (<30 years old) or large cyst (>= 8 cm in diameter) or bilateral cysts is at high risk of recurrence, which is even higher when a patient has more than one of these factors. (C) 2013 Elsevier Ireland Ltd. All rights reserved.