期刊
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
卷 164, 期 2, 页码 176-179出版社
ELSEVIER
DOI: 10.1016/j.ejogrb.2012.06.029
关键词
Implantation failure; Endometrial scraping; Repeated implantation failure
Objective: To evaluate the effect of a single endometrial biopsy regimen (S-EBR) in the cycle preceding the ICSI cycle in patients with repeated implantation failure. Study design: This was a prospective randomized controlled trial which included two-hundred infertile women with a history of repeated implantation failure. The subjects were randomly divided into two groups. Group A subjects underwent hysteroscopy and endometrial scraping by Novak curette in the cycle preceding the ICSI cycle, while group B subjects underwent hysteroscopy without endometrial scraping. Implantation rate, clinical pregnancy rate, abortion rate and live birth rate were compared between both groups. Results: The number of retrieved oocytes in group A was 11.6 +/- 3 and in group B was 11.6 +/- 2.8 with no statistically significant difference (p = 0.787). There were statistically significant differences regarding the implantation rate, the clinical pregnancy rate and live birth rate. The implantation rate in group A was 12% while in group B it was 7% (p = 0.015), the clinical pregnancy rate was 32% in group A while it was only 18% in group B (p = 0.034) and the live birth rate was 28% in group A while it was 14% in group B (p = 0.024). Conclusions: The single endometrial biopsy regimen (S-EBR) performed during hysteroscopy has statistically significant higher implantation rate, clinical pregnancy rate and live birth rate than hysteroscopy without endometrial scraping. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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