期刊
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
卷 39, 期 3, 页码 501-511出版社
SPRINGER
DOI: 10.1007/s00259-011-2003-x
关键词
Lu-177-DOTA-TATE; Dosimetry scan; Ga-68-DOTA-TATE; Neuroendocrine tumour
资金
- Department of Nuclear Medicine/PET Centre, Bad Berka, Germany
Purpose The aim of the study was to compare sequential Lu-177-DOTA-TATE planar scans (Lu-177-DOTA-TATE) in patients with metastasized neuroendocrine tumours (NET) acquired during peptide receptor radionuclide therapy (PRRT) for dosimetry purposes with the pre-therapeutic Ga-68-DOTA-TATE positron emission tomography (PET)/CT (Ga-68-DOTA-TATE) maximum intensity projection (MIP) images obtained in the same patients concerning the sensitivity of the different methods. Methods A total of 44 patients (59 +/- 11 years old) with biopsy-proven NET underwent Ga-68-DOTA-TATE and Lu-177-DOTA-TATE imaging within 7.9 +/- 7.5 days between the two examinations. Lu-177-DOTA-TATE planar images were acquired at 0.5, 2, 24, 48 and 72 h post-injection; lesions were given a score from 0 to 4 depending on the uptake of the radiopharmaceutical (0 being lowest and 4 highest). The number of tumour lesions which were identified on Lu-177-DOTA-TATE scans (in relation to the acquisition time after injection of the therapeutic dose as well as with regard to the body region) was compared to those detected on Ga-68-DOTA-TATE studies obtained before PRRT. Results A total of 318 lesions were detected; 280 (88%) lesions were concordant. Among the discordant lesions, 29 were Ga-68-DOTA-TATE positive and Lu-177-DOTA-TATE negative, whereas 9 were Ga-68-DOTA-TATE negative and Lu-177-DOTA-TATE positive. The sensitivity, positive predictive value and accuracy for Lu-177-DOTA-TATE as compared to Ga-68-DOTA-TATE were 91, 97 and 88%, respectively. Significantly more lesions were seen on the delayed (72 h) Lu-177-DOTA-TATE images (91%) as compared to the immediate (30 min) images (68%). The highest concordance was observed for bone metastases (97%) and the lowest for head/neck lesions (75%). Concordant lesions (n=77; mean size 3.8 cm) were significantly larger than discordant lesions (n=38; mean size 1.6 cm) (p<0.05). No such significance was found for differences in maximum standardized uptake value (SUVmax). However, concordant liver lesions with a score from 1 to 3 in the 72-h (177)LuDOTA- TATE scan had a lower SUVmax (n=23; mean 10.9) than those metastases with a score of 4 (n=97; mean SUVmax 18) (p<0.05). Conclusion Although Lu-177-DOTA-TATE planar dosimetry scans exhibited a very good sensitivity for thedetection of metastases, they failed to pick up 9% of lesions seen on the Ga-68-DOTA-TATE PET/CT. Three-dimensional dosimetry using single photon emission computed tomography/CT could be applied to investigate this issue further. Delayed (72 h) images are most suitable for drawing regions of interest for dosimetric calculations.
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