期刊
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
卷 35, 期 6, 页码 1065-1073出版社
SPRINGER
DOI: 10.1007/s00259-008-0716-2
关键词
[C-11]choline; prostate cancer; PET; CT; anti-androgenic therapy
Purpose The accuracy of positron emission tomography (PET)/CT with [C-11]choline for the detection of prostate cancer is not well established. We assessed the dependence of [C-11]choline maximum standardized uptake values (SUVmax) in the prostate gland on cell malignancy, prostate-specific antigen (PSA) levels, Gleason score, tumour stage and anti-androgenic hormonal therapy. Methods In this prospective study, PET/CT with [C-11]choline was performed in 19 prostate cancer patients who subsequently underwent prostatectomy with histologic sextant analysis (group A) and in six prostate cancer patients before and after anti-androgenic hormonal therapy (bicalutamide 150 mg/day; median treatment of 4 months; group B). Results In group A, based on a sextant analysis with a [C-11]choline SUVmax cutoff of 2.5 (as derived from a receiver-operating characteristic analysis), PET/CT showed sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 72, 43, 64, 51 and 60%, respectively. In the patient-by-patient analysis, no significant correlation was detected between SUVmax and PSA levels, Gleason score or pathological stage. On the contrary, a significant (P < .05) negative correlation was detected between SUVmax and anti-androgenic therapy both in univariate (r(2) = 0.24) and multivariate (r(2) = 0.48) analyses. Prostate [C-11]choline uptake after bicalutamide therapy significantly (P < 0.05) decreased compared to baseline (6.4 +/- 4.6 and 11.8 +/- 5.3, respectively; group B). Conclusion PET/CT with [C-11]choline is not suitable for the initial diagnosis and local staging of prostate cancer. PET/CT with [C-11]choline could be used to monitor the response to anti-androgenic therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据