期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 51, 期 1, 页码 268-281出版社
WILEY
DOI: 10.1111/ejn.14092
关键词
circadian rhythm; neuronal activity; neuropeptide; rest; activity rhythms
资金
- National Institute of General Medical Sciences [T32GM008216]
- National Institute of Neurological Disorders and Stroke [F31NS100395, R37NS048471]
- Howard Hughes Medical Institute
- National Institutes of Health (NIH) [R37 NS048471, T32 GM008216, F31 NS100395]
A central question in the circadian biology field concerns the mechanisms that translate 24-hr oscillations of the molecular clock into overt rhythms. Drosophila melanogaster is a powerful system that provided the first understanding of how molecular clocks are generated and is now illuminating the neural basis of circadian behavior. The identity of 150 clock neurons in the Drosophila brain and their roles in shaping circadian rhythms of locomotor activity have been described before. This review summarizes mechanisms that transmit time-of-day signals from the clock, within the clock network as well as downstream of it. We also discuss the identification of functional multisynaptic circuits between clock neurons and output neurons that regulate locomotor activity.
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