期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 38, 期 11, 页码 3529-3539出版社
WILEY
DOI: 10.1111/ejn.12360
关键词
epilepsy; neurotransmitter; neurotransmitter release; synapse; synaptic proteins
资金
- Consejo Nacional de Ciencia y Tecnologia (CONACyT) [SSA-180069, CB-157863, CB-178567]
- Instituto Nacional de Pediatria [43/2010, 111/2012, 055/2012]
In recent years, there has been considerable interest in determining the function of synaptic vesicle protein 2A and its role as a target for antiepileptic drugs. Although it is known that synaptic vesicle protein 2A is involved in normal synaptic vesicle function, its participation in synaptic vesicle cycling and neurotransmitter release in normal and pathological conditions is unclear. However, the experimental evidence suggests that synaptic vesicle protein 2A could be a vesicular transporter, regulate synaptic exocytosis as a gel matrix, or modulate synaptotagmin-1 activity. This review describes and discusses the participation of synaptic vesicle protein 2A in synaptic modulation in normal and pathological conditions.
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