期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 35, 期 5, 页码 798-804出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1460-9568.2012.08013.x
关键词
addiction; opiates; rats; reinstatement; relapse
资金
- National Institutes of Health [R37-DA06214, T32-DA007288]
- National Institutes of Health from National Center for Research Resources [C06-RR015455]
The orexin/hypocretin system is involved in several addiction-related behaviors. In the present experiments, we examined the involvement of orexin in heroin reinforcement and relapse by administering the orexin 1 receptor antagonist SB-334867 prior to heroin self-administration or prior to cue-induced or heroin-induced reinstatement of extinguished heroin seeking in male Sprague Dawley rats. SB-334867 (30 mg/kg, intraperitoneal) reduced heroin intake during self-administration under fixed ratio-1 and progressive ratio schedules. SB-334867 also attenuated reinstatement of heroin seeking elicited by cues, but not reinstatement elicited by a heroin prime. These results indicate that orexin antagonism reduces heroin self-administration, and they support a role for orexin in cue-triggered drug relapse.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据