期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 35, 期 10, 页码 1533-1539出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1460-9568.2012.08059.x
关键词
barrel cortex; development; thalamocortical; whiskers
资金
- Swiss National Science Foundation [CRSI33_127440]
- 3R Foundation
- Brain and Behavior Research Foundation
- Velux Foundation
- ARSEP
- Novartis Research Foundation
- Swiss National Science Foundation (SNF) [CRSI33_127440] Funding Source: Swiss National Science Foundation (SNF)
The topographical mapping of input is a fundamental organizing principle of sensory pathways. In the somatosensory system, a precise topographical representation of the face is first generated in the brainstem and then faithfully replicated in the thalamus and cortex. Although our knowledge of the distinct polysynaptic pathways that link cutaneous mechanoreceptors of the face with neocortical neurons has recently expanded, the molecular mechanisms controlling their neuron-type-specific assembly during development remain poorly understood. The increasing availability of genetic tools that enable manipulation of these developing circuits with cellular resolution now opens new perspectives in our understanding of the molecular mechanisms through which input from the periphery is converted into patterned central pathways.
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