期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 32, 期 7, 页码 1109-1117出版社
WILEY
DOI: 10.1111/j.1460-9568.2010.07414.x
关键词
animal models; deep brain stimulation; depression; psychiatry
资金
- NARSAD
- Ontario Mental Health Foundation
Deep brain stimulation (DBS) is currently being investigated as a therapy for the treatment of depression. Despite promising results of recent clinical trials, neural and chemical mechanisms responsible for the effects of stimulation are still unclear. In this article, we review clinical and laboratory findings on DBS for depression. Particular emphasis will be given to aspects involved in the translation of data from animal models to humans and in our findings on the potential substrates involved in the antidepressant effects of DBS in rats.
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