期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 32, 期 8, 页码 1239-1244出版社
WILEY
DOI: 10.1111/j.1460-9568.2010.07378.x
关键词
gamma-aminobutyric acid; neuronal development; neurotrophin; synaptic plasticity
资金
- Institut National de la Sante et de la Recherche Mediale (INSERM)
- Centre National de la Recherche Scientifique (CNRS)
- Agence Nationale de la Recherche (ANR)
- Fondation pour la Recherche Medicale (FRM)
During the last decade, a major role has emerged for brain-derived neurotrophic factor (BDNF) in the translation of intrinsic or sensory-driven synaptic activities into the neuronal network plasticity that sculpts neural circuits. BDNF is released from dendrites and axons in response to synaptic activity and modulates many aspects of synaptic function. Although the importance of BDNF in synaptic plasticity has been clearly established, direct evidence for a specific contribution of the activity-dependent dendritic secretion of BDNF has been difficult to obtain. This review summarizes recent advances that have established specific effects of postsynaptic BDNF secretion on synapse efficacy and development. We will also discuss these data in the light of their functional and pathological significance.
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