期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 30, 期 6, 页码 975-986出版社
WILEY
DOI: 10.1111/j.1460-9568.2009.06902.x
关键词
Ca2+-induced apoptosis; calpain-2; CREB; rd1 mouse; retinitis pigmentosa
资金
- Science Foundation Ireland
- Spanish Ministerio de Ciencia e Innovacion [SAF2007-66175]
- Fundacion Medica Mutua Madrilena
- Fundaluce
- Fondo de Investigaciones Sanitarias (Spain)
Retinitis pigmentosa is a heterogeneous group of inherited retinal dystrophies in which the loss of photoreceptor cells via apoptosis leads to blindness. In this study we have experimentally mimicked this condition by treating 661W cells and wild-type mouse retinal explants with a Ca
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