期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 27, 期 11, 页码 2821-2829出版社
WILEY
DOI: 10.1111/j.1460-9568.2008.06266.x
关键词
2-arachidonoylglycerol; anandamide; anxiety; cannabinoid; CB1; N-arachidonylethanolamine
资金
- NIDA NIH HHS [R21 DA 022439, R01 DA016967, F30 DA015575, F30 DA15575, R01 DA016967-03] Funding Source: Medline
Daily life stressors are a major environmental factor contributing to precipitation and exacerbation of mental illness. Animal models using repeated homotypic stress induce anxious and depressive phenotypes and are used to study the pathophysiology of affective disorders. Here we discuss data demonstrating that repeated homotypic stress produces temporally and anatomically distinct changes in endocannabinoid signaling components within stress-responsive brain regions. We also present evidence describing the neural and behavioral correlates of these adaptations in endocannabinoid signaling. These data support a role for endocannabinoid signaling in the central nervous system response to chronic, homotypic stress, and specifically in the process of stress-response habituation. The clinical implications of these findings for the pathophysiology and treatment of affective disorders are discussed.
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