期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 27, 期 5, 页码 1210-1219出版社
WILEY
DOI: 10.1111/j.1460-9568.2008.06101.x
关键词
discrimination; learning; noradrenaline; olfaction; olfactory bulb; rat
The mammalian main olfactory bulb receives a significant noradrenergic input from the locus coeruleus. Norepinephrine is involved in acquisition of conditioned odor preferences in neonatal animals and in some species-specific odor dependent behaviors. Thus far, the role of norepinephrine in odor processing in adult rats remains less studied. We tested the role of noradrenergic modulation in the olfactory bulb of cannulated rats by bilateral injections of vehicle (6 mu L saline), the alpha noradrenergic receptor antagonist phentolamine (3.15 or 10 mM), the beta noradrenergic receptor antagonist alprenolol (12 or 120 mM), the alpha 1 noradrenergic receptor antagonist prazosin (1 or 10(-2) mM) and the alpha 2 noradrenergic receptor antagonist yohimbine (2 or 0.02 mM) 20 min before two different behavioral tasks. We found that local blockade of noradrenergic receptors in the olfactory bulb did not affect the formation of habituation memory to an odorant over sequential presentations separated by 5-min intertrial intervals. However, spontaneous discrimination between chemically related odorants was impaired when noradrenergic receptors, and in particular alpha 1 receptors, were blocked by local antagonist infusion into the olfactory bulb. By contrast, discrimination was improved when beta receptors were blocked. These results show that although the formation of a habituation memory to odorants is not affected by noradrenergic modulation, the specificity of this memory is affected. In contrast, reward-motivated discrimination learning was not impaired, but slowed down in rats in which both alpha and beta receptors had been blocked.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据