期刊
EUROPEAN JOURNAL OF NEUROLOGY
卷 18, 期 3, 页码 387-395出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1468-1331.2010.03187.x
关键词
allergy; glioma; meta-analysis; risk factor
资金
- National '863' High Technique Project [2007AA02Z483]
- Shanghai Rising-Star Program [09QH1402900]
We evaluated the association between allergic conditions and the risk of glioma in case-control and cohort studies published so far on this issue. A total of 12 studies (10 case-control and 2 cohort studies) were included in the analysis, involving 61 090 participants, of whom 6408 had glioma. When compared with non-allergic conditions, the pooled odds ratio (OR) with any allergic conditions for glioma was 0.60 (95% CI: 0.52-0.69, P < 0.001), suggesting a significant negative association (protective effect) between allergy and glioma. Subgroup analysis showed that the ORs were 0.70 (95% CI: 0.62-0.79, P < 0.001), 0.69 (95% CI: 0.62-0.78, P < 0.001), and 0.78 (95% CI: 0.70-0.87, P < 0.001) for asthma, eczema, and hay fever, respectively. The significant association remained even after excluding the bias of proxy reporting (OR = 0.61; 95% CI: 0.50-0.75, P < 0.001). We conclude that allergic conditions may significantly reduce the risk of glioma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据