期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 74, 期 -, 页码 1-6出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2013.12.031
关键词
Maslinic acid; Triterpenoids; Antitumor activity; Apoptosis; Membrane modulation; Cholesterol crystals
资金
- DFG [DFG INST 271/285-1]
Close inspection of human ovarian cancer cells A2780 in the course of an antitumor screening using maslinic acid analogs revealed for one of the compounds, 4-oxa-4-phenyl-butyl 2,3-dihydroxy-olean-12-en-28-oate (1), an unusual behavior. During the incubation of the cells with 1, at the perimeter of the cells or close by crystals were formed consisting of cholesterol and excess 1. Compound 1 was incorporated into the cell's membrane followed by an extrusion of cholesterol from the lipid rafts. As a consequence of the alterations of the cell membrane, a volume decrease was initiated that triggered apoptosis; this extends previous models on apoptosis initiating mechanisms. (C) 2013 Elsevier Masson SAS. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据