期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 74, 期 -, 页码 502-508出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2013.12.051
关键词
Coumarine-derived ligand; Palladium(II) complex; Cytotoxicity; Crystal structure; Apoptosis; Oxidative stress
资金
- Ministry of Education, Science and Technological Development of the Serbia [OI172016, OI172021, III41025]
- Research Center of Serbian Academy of Arts and Sciences
- University of Kragujevac
The new coumarine derivative, 3-(1-(2-hydroxyethylamino)ethylidene)chroman-2,4-dione, and corresponding palladium(II) complex have been synthesized and characterized by microanalysis, infrared, H-1 and C-13 NMR spectroscopy. The proposed structure of the complex was confirmed on the basis of the X-ray structural study. The palladium(II) complex decreased viability of L929 mouse fibrosarcoma, U251 human glioma and B16 mouse melanoma cell lines in a dose dependent manner, while its ligand exhibited no significant cytotoxicity. The cytotoxic effect of the complex was comparable to that of cisplatin, and mediated by apoptosis associated with oxidative stress, mitochondrial depolarization and caspase activation. Therefore, our results indicate that newly synthesized palladium(II) complex might be a potential candidate for anticancer therapy. (C) 2014 Elsevier Masson SAS. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据