期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 80, 期 -, 页码 325-339出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.04.063
关键词
Indole; Amino acid; Anti-fungal; Lanosterol 14 alpha-demethylase
资金
- Department of Science & Technology, New Delhi [SR/S1/OC-82A/2010]
- CSIR
- UGC, New Delhi
Rationally designed compounds consisting of mono- and di-peptide appendages on bis-indole template were synthesized in appreciable yield. Some of these compounds exhibited significant antifungal activities against Candida albicans with their MIC80 in mu g/ml range. However, when used in combination with azoles, the antifungal activities of the azoles were considerably enhanced. The growth inhibition appeared to be specific to the fungal cells and mammalian cells were not affected by these compounds. It is shown that these compounds lower ergosterol levels in the fungal cells and probably act by targeting lanosterol 14 alpha-demethylase, a key enzyme in the sterol biosynthetic pathway of C albicans. The compounds do not appear to directly act on the fungal cell wall. Hence, the sensitivity of the fungal cells to these compounds cannot be attributed to cell wall damage and consequent accumulation of the compounds in the cell, though defects in cell wall due to defective sterol biosynthesis cannot be completely ruled out. (C) 2014 Elsevier Masson SAS. All rights reserved.
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