期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 80, 期 -, 页码 364-382出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.04.013
关键词
Cdc7; MCM2; Kinase inhibitor; DNA replication; Thiazole
The Cell division cycle 7 (Cdc7) protein kinase is essential for DNA replication and maintenance of genome stability. We systematically explored thiazole-based compounds as inhibitors of Cdc7 kinase activity in cancer cells. Our studies resulted in the identification of a potent, selective Cdc7 inhibitor that decreased phosphorylation of the direct substrate MCM2 in vitro and in vivo, and inhibited DNA synthesis and cell viability in vitro. (C) 2014 Elsevier Masson SAS. All rights reserved.
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