Synthesis and evaluation of 4-anilinoquinazoline bioisosteres as potential anti-breast cancer agents

Based on one of the four major categories of scaffold hopping theory namely hetrocycle replacements, a series of 5-arylthieno[2,3-d]pyrimidines had been prepared and evaluated as anti-breast cancer agents. Optimization by combination of different pharmacophores with the thienopyrimidine scaffold led to discovery of biologically active compounds. (c) 2014 Elsevier Masson SAS. All rights reserved.