期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 60, 期 -, 页码 128-134出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2012.11.040
关键词
Fluoroquinolones; Mannich reaction; MRSA; Bactericidal effect
资金
- Research Grant for Young Scientists
A series of novel 1,2,4-triazole-ciprofloxacin hybrids was designed, synthesised and evaluated in vitro against drug-susceptible and drug-resistant bacteria. A significant part of the compounds obtained showed antibacterial activity higher than the activity of ciprofloxacin, both towards Gram-positive and Gram-negative species. Despite relatively small number of synthesised derivatives, it was possible to observe important dependences between their structure and activity. (C) 2012 Elsevier Masson SAS. All rights reserved.
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