期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 70, 期 -, 页码 358-363出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2013.09.060
关键词
Colorectal cancer; Side population (SP) cells; Chromene-2-ones; Indoline-2,3-dione; Hydrazides/hydrazones; Ring-opening
资金
- Deanship of Scientific Research at King Saud University [RGP-VP P-321]
Treatment of ethyl 3-hydrazinyl-3-oxopropanoate (6) with indoline-2,3-dione derivatives 7a g gave ethyl 3-oxo-3-(2-(2-oxoindolin-3-ylidene)hydrazinyl)propanoates 8a g which were allowed to react with the appropriate salicyaldehyde 9a and/or 9b to furnish the chromene-based hydrazones 10a i. Compounds 10a i displayed a significant activity against HT-29 colon cancer cell line and a moderate activity against leukemia 1062 cell line. Compound 10f emerged as the most active congener toward HT-29 colon cancer cell line with IC50 = 7.98 +/- 0.05 jtM whereas compound 10c exhibited the best antiproliferative activity against leukemia K562 cell line with IC50 = 9.44 +/- 0.02 ji.M. Moreover, compound le showed 87.81 7% inhibition of side population (SP) HT-29 colon cancer stem cells. (C) 2013 Elsevier Masson SAS. All rights reserved.
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