期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 67, 期 -, 页码 243-251出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2013.06.052
关键词
[1,2,4]Triazolo[1,5-a]pyridine; Synthesis; Antiproliferative activities; Anticancer effect
资金
- National Natural Science Foundation of China [21072156]
A series of [1,2,4]triazolo[1,5-a]pyridinylpyridines were synthesized and characterized. Their antiproliferative activities in vitro were evaluated by MTT against three human cancer cell lines including HCT-116, U-87 MG and MCF-7 cell lines. The SAR of target compounds was preliminarily discussed. The compounds 1c and 2d with potent antiproliferative activities were tested for their effects on the AKT and p-AKT(473). The anticancer effect of 1c was evaluated in mice bearing sarcoma S-180 model. The results suggest that the title compounds are potent anticancer agents. (C) 2013 Elsevier Masson SAS. All rights reserved.
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