期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 48, 期 -, 页码 26-35出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.11.029
关键词
Copper(II) complexes; N,N ',N ''-trisubstituted guanidines; Cytotoxicity; Crystal structures; Human cell lines
资金
- Higher Education Commission of Pakistan
A series of homoleptic copper(II) complexes (1a-8a) with N,N',N-trisubstituted guanidines, [Cu(II) {PhCONHC(NHR)NPh}(2)] (where R = phenyl (1a), n-butyl (2a), sec-butyl (3a), cyclohexyl (4a), 1-naphthyl (5a), 2,4-dichlorophenyl (6a), 3,4-dichlorophenyl (7a), and 3,5-dichlorophenyl (8a)) have been synthesized and characterized by elemental analyses, FT-IR, UV- visible, H-1 and C-13 NMR spectroscopy, and single crystal X-ray diffraction analysis. The X-ray crystal structures revealed that the complexes 2a and 4a are mononuclear in the solid state and that the geometry around the copper atom is nearly square planar. In both the cases, N,N',N-trisubstituted guanidine ligands have been coordinated to the Cu(II) through the oxygen and nitrogen atoms. The synthesized guanidines and their complexes were initially screened for their anti-microbial activities, and Brine Shrimps Lethality assay. The complexes were also screened for in vitro cytotoxicity activity in human cell lines carcinomas A498, EVSAT, H226, IGROV, M19, MCF-7 and WIDR. The results show a moderate level of cytotoxicity against these seven human cancer cell lines as compared with standard chemotherapeutic drugs. (C) 2011 Elsevier Masson SAS. All rights reserved.
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