期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 54, 期 -, 页码 931-935出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2012.06.025
关键词
Spirulina platensis; Stearic acid; Antidepressant; Estimation of dopamine antimicrobial
资金
- Department of Science and Technology (DST) India [SR/SO/HS-0143-2009]
Stearic acid, a saturated fatty acid was isolated from the microalga Spirulina platensis. Some novel stearic acid analogues having 1,3,4-oxadiazole, 1,2,4-triazole and 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole are synthesized and characterized by IR, NMR and mass spectral analysis. All the synthesized compounds were screened for antimicrobial activity by using cup plate method. The synthesized compounds have been further screened for their antidepressant activity in swiss albino mice by forced swim test (FST), midbrain dopamine has been estimated and quantified. All the compounds showed good antimicrobial activity and compound 6 showed significant antidepressant activity. (C) 2012 Elsevier Masson SAS. All rights reserved.
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