期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 54, 期 -, 页码 239-247出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2012.05.004
关键词
Quinoline; Antimicrobial activity; Multicomponent reaction; IC50
资金
- UGC, New Delhi
A new series of N-arylamino biquinoline derivatives 5a-x were synthesized by reaction of 2-chloro-3-formyl quinolines 2a-d with malononitrile and various enhydrazinoketones 4a-f in absolute ethanol. The newly synthesized compounds were evaluated for their in vitro antimicrobial activity against a representative panel of pathogenic strains and antituberculosis activity against Mycobacterium tuberculosis H37Rv. Compounds Sh and Ss exhibited excellent antibacterial activity and some of the compounds demonstrated moderate antituberculosis activities compared with the first line drugs. The compounds were evaluated in vitro for their activity against the growth of Plasmodium falciparum, the malaria causing parasite. Some of them showed antimalarial activity with IC50 values as low as 0.005-0.009 mu g/mL. (C) 2012 Elsevier Masson SAS. All rights reserved.
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