期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 2, 页码 765-772出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.12.015
关键词
alpha-Cyanocinnamonitriles; Ethyl alpha-cyanocinnamates; 3-N,N-Diethylaminophenol; 4H-Chromene; Coumarin; 12H-Chromeno[2,3-d]pyrimidine; Antimicrobial; Cytotoxicity
Condensation of 3-N,N-diethylaminophenol (1) with alpha-cyanocinnamonitriles (2a-c) and ethyl alpha-cyanocinnamates (2d-f) provided compounds 3a-f and 4a-c. 12H-Chromeno[2,3-d]pyrimidine derivatives 6,11-13 and 16 were obtained by treatment of 4H-chromene compounds (3) with different electrophiles followed by nucleophilic reagents. Structures of these compounds were established on the basis of IR, UV, H-1 NMR, C-13 NMR and MS data. Some of the new compounds were evaluated for antimicrobial and cytotoxicity activities. (C) 2010 Elsevier Masson SAS. All rights reserved.
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