期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 2, 页码 691-703出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.12.004
关键词
3,5-Diaryl isoxazoline/isoxazole; 2,3-Dihydroquinazolinones; Cytotoxicity; Cell cycle effects; Tubulin depolymerization
资金
- CSIR, New Delhi
A series of new 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydro quinazolinone hybrids with different linker architectures have been designed and synthesized. These compounds have been evaluated for their anticancer activity. One of the compounds 4c amongst this series has shown promising anticancer activity. Further some detailed biological assays relating to the cell cycle aspects and tubulin depolymerization activity have been examined with a view to understand the mechanism of action of this conjugate. (C) 2010 Elsevier Masson SAS. All rights reserved.
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