Synthesis and antimicrobial evaluation of new benzofuran derivatives

Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus sub fills, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC80 = 0.39-3.12 mu g/mL), which were better than the control drugs. (C) 2011 Elsevier Masson SAS. All rights reserved.