期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 6, 页码 2441-2452出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.03.029
关键词
Ischemia/reperfusion injury; Anti-inflammatory activity; Analgesic activity; beta-carboline-tripeptide conjugate
资金
- NASA [MSGC R85197]
- Research Excellence Fund [R01121]
- Natural Science Foundation of HeBei, China [062761266]
- Administration of Traditional Chinese Medicine of HeBei Province [2007134]
We have synthesized a series of new beta-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that beta-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat. Published by Elsevier Masson SAS.
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