期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 6, 页码 2152-2156出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.02.069
关键词
Lipase; Cytotoxicity; Neuroblastoma cell line (SK-N-SH); Lung carcinoma A549 cell line
资金
- University Grant Commission (UGC), New Delhi
Synthesis, characterization, resolution and evaluation of novel (R/S)-2-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl]-1H-pyrrolo[3,4-b]quinolin-3(2H)-one derivatives are described. Enantiomerically pure compounds were isolated in good to excellent yield with high enantiomeric excess under mild reaction conditions by using Candida antarctica B (CAL-B) and Candida rugosa (CRL) Lipases. Newly synthesized and resolved compounds were screened for their antitumor activity against cancer cells such as human neuroblastoma SK-N-SH and human lung carcinoma A549 cell line in vitro. The results have shown that the compound 1 S-(-) alcohol was more effective in inhibiting the tumor cell growth. (C) 2011 Elsevier Masson SAS. All rights reserved.
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