期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 7, 页码 3030-3037出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.04.040
关键词
Naphthalimide; Fluorescent marker; Hypoxic; N-Oxide; Bioreduction
资金
- Key New Drug Creation and Manufacturing Program [2009ZX09103-102]
- China 111 Project [B07023]
- Shanghai Leading Academic Discipline Project [B507]
- Shanghai Foundation of Science and Technology [073919109]
A series of novel aliphatic N-oxide of naphthalimides (A1-A5) were designed and prepared. The N-O group was firstly introduced into the amine side chain tailed to planar naphthalimide chromophore as hypoxic bioreductive marker. Fluorescence image analysis showed that the compounds could be used as potential markers for hypoxic cells (V79) in vitro especially for A1 with 17 times hypoxic-oxic fluorescence differential, which was probably due to the bis-bioreduction mechanism. (C) 2011 Elsevier Masson SAS. All rights reserved.
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