期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 12, 页码 5991-6001出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.10.011
关键词
Maslinic acid derivatives; Synthesis; Cytotoxicity; Anticancer activity; Apoptosis
资金
- Direccion General de Programas y Transferencia de Conocimiento
- Ministerio de Ciencia e Innovacion
Maslinic acid (2 alpha,3 beta-dihydroxyolean-12-en-28-oic acid), a natural dihydroxylated pentacyclic triterpene acid isolated from olive-pressing residues, has been investigated together with some of its derivatives regarding the induction of apoptosis in B16F10 melanoma cells. Some of the compounds tested are described in this work, but others come from previous studies. Ten of these derivatives induce over 80% of apoptosis, clearly promoting cell death in B16F10 melanoma. By contrast, the induction cell death through necrosis was very slightly significant with these compounds. These results indicate that maslinic acid derivatives are promising chemopreventive and chemotherapeutic agents. (C) 2011 Elsevier Masson SAS. All rights reserved.
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